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While the minimum dose for steroid-induced bone loss is unknown, reduced bone density and fractures have occurred with doses as low as 5mg of prednisone per dayin adults, and the low end of doses has also been shown in adolescents. DosageThe recommended dosages of prednisone in children are as follows:Prescription Dosage:In adults:Adult 1 year of age and older: 15mg daily, divided twice dailyAdult 2 to 23 years of age: 15mg daily, divided once dailyAdult 24 to 64 years of age: 15mg daily, divided once dailyPre-existing conditions:Adult: Any bone disease, including osteoporosis (pre-existing fracture, osteonecrosis, or osteopenia); orInfants and children: Any bone disorder or bone defect (especially a fracture, osteonecrosis, or osteopenia); orAdults with serious heart or pulmonary disease: Any heart condition, including coronary artery disease, or emphysema; orPregnancy: Breast-feeding or potential congenital anomaly; orAny other condition, other than those listed above.Table 1: Recommended Adult Dosage of Prednisone in ChildrenChildren (0 to 18 Years) Adult 1 Years of Age and Older 25mg daily, divided twice daily (adult and child)1 to 3 years of age 25mg daily, divided twice daily (adult and child)4 to 6 years of age 25mg daily, divided twice daily (adult and child)7 years of age; orAdults with serious heart, lung, or liver disease: Any heart condition, including coronary artery disease, emphysema, or pulmonary embolism; orPregnancy: Breast-feeding or potential congenital anomaly; orAny other condition other than those listed above.Recommendations for Pediatric PatientsBased on the available scientific evidence and clinical experience with prednisone (not including children and adolescents with serious heart, lung, or liver disease), the FDA recommended the following:Pre-existing ConditionsThe FDA also recognized that pediatric patients with serious heart, lung, or liver disease are at greater risk for prednisone toxicity. Pediatric patients requiring medical treatment for serious heart, lung, or liver disease should not receive prednisone for the treatment of their condition without consideration of the clinical and toxic effects of that medicine.Steroid Treatment of Heart DiseaseThe FDA has indicated that, at theRelated Article: